Copenhageni M 20 1938,1966
The strain M 20 was isolated by Borg-Petersen (1938) from a patient in Denmark. It was shown by agglutin-absorption tests to differ serologically from strain RGA. The strain M 20 is able to absorb nearly all antibodies from RGA antiserum whereas strain RGA only removes its homologous antibodies from M 20 antiserum. The strain was therefore considered to represent a 'subtybe' of serovar Icterohaemorrhagiae.
Gisben and Schüffner (1939) confirmed the serological results but they classified M 20 as the 'complete biotype' of icterohaemorrhagiae, and named it icterohaemorrhagiae AB. The strain was later considered to represent 'a subserotype' of Icterohaemorrhagiae (WHO, 1965). Kmety (1966), who studied the antigenic structure of serovars of the Icterohaemorrhagiae serogroup, suggested abandoning the taxonomic rang of 'subserotypes' and proposed that M 20 should represent a 'serotype' named copenhageni. This suggestion was accepted by the TSC 1966 at their Moscow meeting in 1966 (TSC meeting, 1966: Statements and Recommendations, 1971).
* Borg-Petersen Ch. Leptospirenuntersuchungen in Danemark. Acta Conv. Tert. de Trop. Ataque Malariae Morbis 1, Amsterdam, 1938, 396-404.
* Gispen R., Schuffner W. Die Spaltung der klassischen L. icterohaemorrhagiae in zwei Biotypen. Zbl. Bakt. I. Abt. Orig. 144, 1939, 427-434.
* WHO: Classification on Leptospires and Recent Advances in Leptospirosis. Bull. Wld. Hlth. Org. 32, 5, 1965, 881-891.
* TSC meeting, 1966, Moscow: Minutes. Int. J. Syst. Bacteriol. 21, 1971, 138-139.
* TSC meeting, 1966: Statements and Recommendations. Int. J. Syst. Bacteriol. 21, 1971, 142-146.
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Reactions between reference strains and monoclonal antibodies
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